The following are some examples of Process Intensifying Continuous Process Flow Reactions which SBI has used to manufacture an array of advanced intermediates.

With the Mitsunobu Reaction intermolecular substitution leads to esters, ethers, thioethers, isothiocyanates and amines. Via the intramolecular variant, lactones and lactams can be achieved.

Application of Mitsunobu reactions: orlistat (Xenical®, Hoffmann LaRoche): Anti-obesity. Eletriptan: Anti-migraine (Pfizer)

Application of Heck reactions: Eletriptan: Anti-migraine (Pfizer); Naratriptan: Anti-migraine (Glaxo SmithKline); Substituted Indoles

Application of Suzuki reactions: Valsartan: Anti-hypertensive (Novartis); Boscalid: Fungicide (Abbott); GR127935: Anti-hypertensive (Glaxo SmithKline)

Application of asymmetric hydrogenation reactions:       Atorvastatin (Lipitor®, Pfizer);  UK-396,082-03, Anti-thrombotic agent; Tipranavir: Anti-HIV drug (Pfizer); levofloxacin: Anti-bacterial; L-Dopa Anti-Parkinson’s

Application of tryptamine intermediates: Sumatriptan (Imitrex®, Glaxo SmithKline): Anti-migraine; Melatonin; 5-Hydroxytryptamine

Application of Grignard reagents: Voriconazole: Anti-fungal (Pfizer); Itraconazole: Anti-fungal (Pfizer);