Introducing

AIMS proprietary Process Intensifying Continuous Flow-Through Reaction (PICFTR) reactor systems and Technologies

PICFTR Technology

AIMS proprietary Process Intensifying Continuous Flow-Through Reaction (PICFTR) reactor system allows rapid scale up of routine and highly energetic reactions and use of dangerous and sensitive chemicals such as Hydrazoic acid and organometallics etc., routinely and safely.

Specially Designed Modular PICFTR Reactor System:

AIMS’s specially designed reactor system speeds up reactions by influencing reaction kinetics, thereby intensifying processing and cut down reaction time from hours to seconds.

Fine chemical production, a critical stage of the pharmaceutical research, development, and manufacturing process, typically occurs in a batch environment. A superior alternative production methodology known as continuous processing technologies can reduce operating expenses by 90% and capital expenses by 50%. AIMS can perform processing continuous reactions, involving sensitive and dangerous reagents routinely, safely and economically.

In particular, AIMS leverages continuous process manufacturing technologies for specialty chemicals and active pharmaceutical ingredients AIMS has developed expertise in processing reactions continuously, involving sensitive and dangerous reagent routinely, safely and economically.

Reagents handled

Asymmetric reactions
Alkoxides
BF3
Boranes
Butyl lithium
CF₂Br₂
Grignards
hydrazoic acid
hydrogen cyanide
Homogeneous and Heterogeneous catalysts for Hydrogenation
Triphosgene

AIMS' PICFTR speeds up reactions by influencing and intensifying kinetics. As a result of this reaction-time can be reduced by manifolds, Reaction that normally take several hours can be run in few second retention time in specially designed proprietary & modular Process Intensifying Continuous Flow-Through Reaction (PICFTR) reactor system. It reduces labor and reactor sizes especially for large volume production.

Due to very short contact time, side reactions are minimized or completely eliminated resulting into very consistent quality and better purity of product time and time again.

Adaptability

Modular system is highly adaptable and moldable to individual process requirements to handle:

Liquid phase reaction to
Slurry and gas-liquid reactions.
Homogeneous or Fixed bed catalysis
Low to 200^oC temperatures
Normal to 2000 psi pressure

This technology enables AIMS to develop processes for the efficient production of high quality and high value fine chemicals, a sustainable competitive advantage that competitors are unable to provide. This novel approach to chemical synthesis allows the performance of larger batch reactions by rapid cycling of minute batches with a high degree of accuracy and reproducibility. This reduction in size lessens various risks that affect the scalability of some difficult reactions, while decreasing the cost by almost eliminating the problems that are related to very large sized batch reactions (e.g. safety, cost of facilities, manpower, and overhead costs that are prevalent throughout the pharmaceutical industry).

Advantages

Compared to traditional batch or continuous processing, AIMS's PICFTR technology's extends following advantages:

Improved Kinetics: Reduces reaction time from hours to seconds by influencing reaction kinetics. AIMS' designed proprietary PICFTR reactor system with superior mixing and heat exchange intensify reaction.

Handling of Energetic Exothermic Reactions: PICFTR can handle highly energetic reactions that are simply not possible on commercial scale in batch or even using other prevalent continuous processing technologies that are designed to accommodate only retention time.

Improved Quality and Yield: PICFTR technology allows the performing of larger volume reactions by rapid cycling of minute batches with a high degree of accuracy and reproducibility. PICFTR technology enables precise control on process parameters in real time. This is a significant improvement over standard batch reactions, where process parameters are hard to control due to large volumes involved. With precise control a reproducible consistency in quality is assured.

Increased Flexibility and Scalability: PICFTR technology enables greater flexibility in production run sizes, which can be changed without making any modification in design or equipment size, thereby maintaining strict process parameters without compromising on quality and yields. Hence, to increase production, only run time has to be increased and not the run size

Improved Safety and Environmental Impact: With the reduction in volumes of the reactants reacting at any given moment to almost miniscule levels, various risks that affect the scalability of some difficult reactions are virtually eliminated. This, in turn, reduces the risk of accidents by almost eliminating the problems that are related to the more common very large size batch reactions.

Reduced Costs: PICFTR provides several-fold cost reduction compared with current manufacturing techniques due to lower initial capital expenditures, the increase in quality of output, and process automation. In particular, the superior performance of CFTR technology allows operation at optimal reaction conditions, at higher concentrations or solvent less thereby minimizing raw materials wastage as well as the volumes of solvents and by-products that need to be handled or disposed off. Similarly, process automation results in increased efficiency and reduced labor costs.

Reduced Energy Consumption: PICFTR technology can operate with highly concentrated reactants that reduce energy consumption by up to 30%. In contrast, in batch production, a large amount of solvent has to be used to dilute the reactants, consequently requiring energy demanding evaporation.

Homogenous Hydrogenation Catalysts for asymmetric reduction for Continuous processing:

AIMS Fine Chemicals is capable of developing, producing and using several homogenous hydrogenation catalysts for asymmetric reduction.

Patent Protection & Technology Transfer:

AIMS work with clients under complete confidentiality and transparency. Processes developed on behalf of client are transferred to client for patent protection and for manufacturing quantities beyond AIMS' capacity. AIMS does not hold IP. Some clients like to acknowledge AIMS contribution by filing patents jointly.

AIMS' PICFTR - Chemistry Capabilities

Following are some of the examples where our Process Intensifying Continuous process Flow Reactions can be applied to manufacture an array of advanced intermediates.

Mitsunobu Reaction

With the Mitsunobu Reaction intermolecular substitution leads to esters, ethers, thioethers, isothiocyanates and amines. Via the intramolecular variant, lactones and lactames can be achieved.

Application of Mitsunobu Reaction:

Orlistat / Xanical: Anti-obesity (Hoffman La Roche)

Eletriptan (Triptans): Migraine (Pfizer)